Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967832 | 0.81 | KDM4E (0.58) | HRH3RAB9AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL2733870 | 0.79 | SIGMAR1 (0.51) | HRH3MEN1KMT2ALTA4HACHE | |
| SCHEMBL23775592 | 0.78 | RAB9A (0.58) | HRH3RAB9AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL16176142 | 0.78 | RAB9A (0.66) | HRH3RAB9AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL1586714 | 0.77 | SIGMAR1 (0.63) | MEN1KMT2AACHE | |
| SCHEMBL8101249 | 0.77 | SIGMAR1 (0.63) | MEN1KMT2AACHE | |
| SCHEMBL15021034 | 0.77 | HRH3 (0.48) | HRH3RAB9AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL23775702 | 0.77 | MEN1 (0.57) | HRH3RAB9AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL8791222 | 0.76 | HRH3 (0.66) | HRH3ALDH1A1KMT2ALTA4H | |
| SCHEMBL15037422 | 0.76 | POLB (0.53) | HRH3RAB9AMEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0111397-B1 | ISOINDOLE DERIVATIVES, PREPARATION, AND USES | Bristol-Myers Company (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4600758-A | 5-SULFAMOYL-3-OXOISOINDOLES WITH ARLYPIPERIDINYL MOIETIES, DIURETICS, HYPOTENSIVES | MEAD JOHNSON & COMPANY (US) | 1986-07-15 | — | — | US | disclosed |
| US-4495194-A | HYPOTENSIVE AGENTS; DIURETICS | MEAD JOHNSON & COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0111397-A1 | Isoindole derivatives, preparation, and uses | Bristol-Myers Company (US) | 1984-06-20 | — | — | EP | disclosed |