SCHEMBL10499403

SCHEMBL10499403

CCCN1CCN(c2ccc([N+](=O)[O-])cc2)C1=O

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 5/20 0.48
SIRT6 Q8N6T7 1/20 0.48
DRD2 P14416 5/20 0.47
DRD3 P35462 5/20 0.47
S1PR1 P21453 1/20 0.45
LMNA P02545 2/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10498419 0.92 CYP1A1 (0.54) CYP1A1SIRT6DRD2DRD3S1PR1
SCHEMBL10498805 0.88 SIRT6 (0.46) SIRT6DRD2DRD3LMNAMAPT
SCHEMBL6224468 0.86 DRD2 (0.47) SIRT6DRD2DRD3LMNAMAPT
SCHEMBL31011685 0.81 MAPT (0.56) SIRT6LMNAMAPTALDH1A1KCNH2
SCHEMBL3710958 0.80 DRD2 (0.52) CYP1A1DRD2DRD3S1PR1KCNH2
SCHEMBL5362388 0.80 SIRT6 (0.54) SIRT6LMNAMAPTALDH1A1SMN1; SMN2
SCHEMBL13666661 0.80 LMNA (0.47) SIRT6LMNAMAPTALDH1A1SMN1; SMN2
SCHEMBL14698020 0.79 DRD2 (0.65) CYP1A1DRD2DRD3S1PR1KCNH2
SCHEMBL14119519 0.78 CYP1A1 (0.65) CYP1A1
SCHEMBL4710512 0.78 LMNA (0.45) SIRT6DRD2DRD3LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4861879-A VAGINAL FUNGICIDE JANSSEN PHARMACEUTICA N.V. (BE) 1989-08-29 US disclosed
EP-0118138-B1 ((4-(4-(4-PHENYL-1-PIPERAZINYL)PHENOXYMETHYL)-1,3-DIOXOLAN-2-YL)METHYL)-1H-IMIDAZOLES AND 1H-1,2,4-TRIAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1989-06-14 EP disclosed
US-4735942-A FUNGICIDE, BACTERICIDE PARTICULARLY FOR UROGENITAL DISORDERS JANSSEN PHARMACEUTICA, N.V. (BE) 1988-04-05 US disclosed
US-4619931-A BACTERICIDES, FUNGICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1986-10-28 US disclosed
EP-0118138-A1 ((4-(4-(4-Phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazoles and 1H-1,2,4-triazoles JANSSEN PHARMACEUTICA N.V. (BE) 1984-09-12 EP disclosed