SCHEMBL10499411

SCHEMBL10499411

O=[N+]([O-])c1cc(Cl)cnc1Oc1ccc(O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.62
LMNA P02545 2/20 0.50
CYP2C9 P11712 1/20 0.50
TSHR P16473 1/20 0.50
APEX1 P27695 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
PIN1 Q13526 4/20 0.46
PDE7A Q13946 1/20 0.44
MERTK Q12866 1/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
ATM Q13315 1/20 0.42
LIPE Q05469 3/20 0.41
PPARG P37231 1/20 0.39
MAPT P10636 3/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307928 0.86 LMNA (0.50) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL306660 0.86 PIN1 (0.62) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL4914975 0.83 MERTK (0.56) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL4913347 0.82 MAPT (0.56) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL11013133 0.81 ALDH1A1 (0.51) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL9175457 0.80 L3MBTL1 (0.49) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL4915024 0.80 CYP2C9 (0.47) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL4911112 0.80 LMNA (0.55) LMNACYP2C9TSHRAPEX1SMN1; SMN2
SCHEMBL10475397 0.79 MAPT (0.53) MAPK1LMNACYP2C9TSHRAPEX1
SCHEMBL11017217 0.78 PIN1 (0.44) MAPK1LMNACYP2C9TSHRAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0305593-A2 Intermediates for cyanamides of 2-pyridinyloxyphenoxypropionic acid CIBA-GEIGY AG (CH) 1989-03-08 EP claimed
EP-0148119-B1 AMIDES OF 2-PHENOXYPROPIONIC ACID CIBA-GEIGY AG (CH) 1989-05-03 EP disclosed
EP-0305593-A2 Intermediates for cyanamides of 2-pyridinyloxyphenoxypropionic acid CIBA-GEIGY AG (CH) 1989-03-08 EP disclosed
US-4759796-A Used together with a carrier and other adjuvant CIBA-GEIGY CORPORATION (US) 1988-07-26 US disclosed
US-4640703-A CONTROLLING GRASSES IN CROPS CIBA-GEIGY CORPORATION (US) 1987-02-03 US disclosed
EP-0148119-A2 Amides of 2-phenoxypropionic acid CIBA-GEIGY AG (CH) 1985-07-10 EP disclosed