Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501872 | 0.85 | METAP2 (0.62) | MEN1KMT2ASCN2AKDM4EMAPT | |
| SCHEMBL10503512 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2ASCN2AKDM4EMAPT | |
| SCHEMBL10502345 | 0.82 | ALDH1A1 (0.50) | MEN1KMT2AKDM4EMAPTMETAP2 | |
| SCHEMBL10501842 | 0.79 | METAP2 (0.49) | MEN1KMT2AKDM4EMAPTMETAP2 | |
| SCHEMBL10501265 | 0.78 | MPI (0.49) | MEN1KMT2AMAPTMETAP2ALDH1A1 | |
| SCHEMBL10502143 | 0.78 | METAP2 (0.45) | MEN1KMT2AMAPTMETAP2ALDH1A1 | |
| SCHEMBL10747422 | 0.76 | MEN1 (0.41) | MEN1KMT2AKDM4EMAPTMETAP2 | |
| SCHEMBL10501589 | 0.76 | METAP2 (0.61) | MEN1KMT2AKDM4EMAPTMETAP2 | |
| SCHEMBL10502481 | 0.76 | METAP2 (0.46) | MEN1KMT2AKDM4EMAPTMETAP2 | |
| SCHEMBL10501084 | 0.76 | METAP2 (0.68) | MEN1KMT2AKDM4EMAPTMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |