Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502531 | 0.89 | MAT2A (0.40) | MAT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10501557 | 0.84 | CD274 (0.34) | MAT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10743453 | 0.84 | METAP2 (0.34) | MAT2AALDH1A1MAPTKDM4EAGTR1 | |
| SCHEMBL5916634 | 0.83 | METAP2 (0.45) | MAT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10502474 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAPTKDM4ELMNAHTT | |
| SCHEMBL10501980 | 0.80 | METAP2 (0.41) | ALDH1A1MAPTKDM4ELMNAHTT | |
| SCHEMBL10501411 | 0.79 | METAP2 (0.38) | MAT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10502370 | 0.78 | KMT2A (0.42) | ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10502151 | 0.78 | METAP2 (0.44) | MAT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10502337 | 0.75 | ALDH1A1 (0.38) | ALDH1A1MAPTKDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |