Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.40 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.40 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502051 | 0.91 | SLC11A2 (0.40) | METAP2SLC11A2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL10746448 | 0.85 | TXNRD1 (0.43) | METAP2TXNRD1TXNRD3TXNRD2ALDH1A1 | |
| SCHEMBL10501793 | 0.85 | TXNRD1 (0.52) | METAP2TXNRD1TXNRD3TXNRD2SLC11A2 | |
| SCHEMBL10501631 | 0.80 | MAT2A (0.38) | METAP2ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL10503543 | 0.80 | METAP2 (0.50) | METAP2TXNRD1TXNRD3TXNRD2ALDH1A1 | |
| SCHEMBL11020733 | 0.79 | METAP2 (0.38) | METAP2TXNRD1TXNRD3TXNRD2ALDH1A1 | |
| SCHEMBL10502474 | 0.79 | ALDH1A1 (0.38) | METAP2ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL5916746 | 0.78 | METAP2 (0.53) | METAP2TXNRD1TXNRD3TXNRD2SLC11A2 | |
| SCHEMBL10748075 | 0.77 | MAPT (0.40) | METAP2ALDH1A1KDM4EMAPT | |
| SCHEMBL10501833 | 0.76 | NPC1 (0.43) | METAP2TXNRD1TXNRD3TXNRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |