Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502686 | 0.91 | KDM4E (0.44) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL11005782 | 0.90 | CYP2C9 (0.46) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL10786375 | 0.87 | CYP2C9 (0.61) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL11003338 | 0.85 | ACHE (0.44) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL10503447 | 0.83 | DHFR (0.43) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL11001264 | 0.82 | CYP2C9 (0.49) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL10502963 | 0.82 | CACNA1C (0.43) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10789103 | 0.81 | KDM4E (0.58) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL11034438 | 0.81 | CACNA1D (0.44) | CYP2C9CYP3A4CYP2C19TSHRLMNA | |
| SCHEMBL10924654 | 0.79 | CYP2C9 (0.42) | CYP2C9CYP3A4CYP2C19TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133530-B1 | 1,6-NAPHTHYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |
| EP-0133530-A2 | 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1985-02-27 | — | — | EP | disclosed |