Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10791132 | 0.87 | ACHE (0.54) | DHFRHSD17B10ACHECYP2C9CYP2C19 | |
| SCHEMBL11000277 | 0.85 | TNF (0.38) | DHFRHSD17B10ACHECYP2C9CYP2C19 | |
| SCHEMBL10502963 | 0.85 | CACNA1C (0.43) | ACHE | |
| SCHEMBL11034438 | 0.84 | CACNA1D (0.44) | HSD17B10ACHECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL10503261 | 0.83 | CYP2C9 (0.48) | HSD17B10CYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL11035332 | 0.82 | DHFR (0.44) | DHFRHSD17B10ACHECYP2C9CYP2C19 | |
| SCHEMBL11360232 | 0.77 | DHFR (0.47) | DHFRHSD17B10ACHECYP2C9CYP2C19 | |
| SCHEMBL10502686 | 0.77 | KDM4E (0.44) | HSD17B10CYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL10999744 | 0.76 | CACNA1F (0.53) | CYP2C9CYP2C19MEN1KMT2APOLB | |
| SCHEMBL10915404 | 0.76 | DHFR (0.46) | DHFRHSD17B10ACHECYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133530-B1 | 1,6-NAPHTHYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |
| EP-0133530-A2 | 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1985-02-27 | — | — | EP | disclosed |