Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.35 |
| ▸ | CASR | P41180 | 9/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10504207 | 0.98 | HTR1A (0.35) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10505428 | 0.89 | ADRB1 (0.41) | ADRB2ADRB1ADRB3 | |
| SCHEMBL10503738 | 0.86 | HTR1A (0.36) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10503937 | 0.82 | HTR1A (0.56) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10595545 | 0.80 | HTR1A (0.42) | HTR1AADRA2AADRB2ADRB1CASR | |
| SCHEMBL10504063 | 0.79 | HTR1A (0.55) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10506787 | 0.78 | ADRB2 (0.37) | ADRB2ADRB1CASRADRB3 | |
| SCHEMBL10505401 | 0.78 | ADRB2 (0.40) | ADRB2ADRB1CASRADRB3 | |
| SCHEMBL10592061 | 0.78 | CASR (0.50) | ADRB2ADRB1CASRADRB3 | |
| SCHEMBL10594588 | 0.78 | CYP2D6 (0.45) | ADRB2ADRB1CASRCYP2D6ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |