SCHEMBL1050683

SCHEMBL1050683

O=Cc1ccc(OCc2ccccc2)c(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.68
NPC1 O15118 6/20 0.68
RAB9A P51151 6/20 0.68
NFKB1 P19838 2/20 0.68
NFKB2 Q00653 2/20 0.68
RELA Q04206 2/20 0.68
HPGD P15428 5/20 0.60
PPARG P37231 1/20 0.60
MAOA P21397 1/20 0.56
MAOB P27338 1/20 0.56
TACR2 P21452 1/20 0.55
EGFR P00533 1/20 0.51
ALDH1A1 P00352 4/20 0.49
MAPT P10636 5/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL414613 0.88 TACR2 (0.70) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL560188 0.88 MAOA (0.56) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL29446267 0.85 TACR2 (0.62) SMN1; SMN2NPC1RAB9AHPGDMAOA
SCHEMBL584489 0.85 TACR2 (0.62) SMN1; SMN2NPC1RAB9AHPGDMAOA
SCHEMBL23496294 0.85 TACR2 (0.59) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL15774354 0.85 CISD1 (0.58) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL1299319 0.85 HPGD (0.61) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL12516172 0.84 RAB9A (0.68) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL15774835 0.84 MAOA (0.63) SMN1; SMN2NPC1RAB9ANFKB1NFKB2
SCHEMBL5216320 0.84 TACR2 (0.78) SMN1; SMN2NPC1RAB9ANFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4374877-A2 PHARMACEUTICAL CONTAINING SODIUM-DEPENDENT PHOSPHATE TRANSPORTER INHIBITOR AND PHOSPHORUS ADSORBENT FOR USE IN THE PREVENTION, TREATMENT OR SUPPRESSION OF CHRONIC KIDNEY DISEASE, ARTERIOSCLEROSIS ASSOCIATED WITH VASCULAR CALCIFICATION, OR ECTOPIC CALCIFICATION. CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-05-29 EP disclosed
EP-3928779-B1 PHARMACEUTICAL CONTAINING SODIUM-DEPENDENT PHOSPHATE TRANSPORTER INHIBITOR AND PHOSPHORUS ADSORBENT FOR USE IN THE PREVENTION, TREATMENT OR SUPPRESSION OF CHRONIC KIDNEY DISEASE, ARTERIOSCLEROSIS ASSOCIATED WITH VASCULAR CALCIFICATION, OR ECTOPIC CALCIFICATION. CHUGAI PHARMACEUTICAL CO LTD (JP) 2024-03-06 EP disclosed
US-20230357134-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS UCL BUSINESS LTD (GB) 2023-11-09 US disclosed
US-20230357134-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS UCL BUSINESS LTD (GB) 2023-11-09 US disclosed
US-20230357134-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS UCL BUSINESS LTD (GB) 2023-11-09 US disclosed
EP-4214189-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS UCL Business Ltd (GB) 2023-07-26 EP disclosed
WO-2022058733-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS UCL BUSINESS PLC (GB) 2022-03-24 WO disclosed
EP-3928779-A1 PHARMACEUTICAL CONTAINING SODIUM-DEPENDENT PHOSPHATE TRANSPORTER INHIBITOR AND PHOSPHORUS ADSORBENT FOR USE IN THE PREVENTION, TREATMENT OR SUPPRESSION OF CHRONIC KIDNEY DISEASE, ARTERIOSCLEROSIS ASSOCIATED WITH VASCULAR CALCIFICATION, OR ECTOPIC CALCIFICATION. Chugai Seiyaku Kabushiki Kaisha (JP) 2021-12-29 EP disclosed
EP-3192511-B1 PHARMACEUTICAL CONTAINING SODIUM-DEPENDENT PHOSPHATE TRANSPORTER INHIBITOR CHUGAI PHARMACEUTICAL CO LTD (JP) 2021-07-14 EP disclosed
CN-107072993-B Pharmaceutical containing sodium-dependent phosphate transporter inhibitor 中外制药株式会社 2021-02-12 CN disclosed
US-6683095-B2 ANTICARCINOGENIC AGENTS; ANTIPROLIFERATION AGENTS LG LIFE SCIENCES LTD. (KR) 2004-01-27 US disclosed
WO-2004007453-A1 PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE OXFORD GLYCOSCIENCES (UK) LTD (GB) 2004-01-22 WO disclosed
CN-1433410-A CDK inhibitors having 3-hydroxychromen-4-one structure LG LIFE SCIENCES CO LTD (KR) 2003-07-30 CN disclosed
US-20030125356-A1 Cdk inhibitors having 3-hydroxychromen-4-one structure LG LIFE SCIENCES LTD. (KR) 2003-07-03 US disclosed
EP-1280789-A1 CDK INHIBITORS HAVING 3-HYDROXYCHROMEN-4-ONE STRUCTURE LG Life Sciences Ltd. (KR) 2003-02-05 EP disclosed
WO-2001083469-A1 CDK INHIBITORS HAVING 3-HYDROXYCHROMEN-4-ONE STRUCTURE LG LIFE SCIENCES LTD. (KR) 2001-11-08 WO disclosed
US-4649160-A HYPOTENSIVE, ANTIARRHYTHMIA, ADRENERGIC BLOCKING AGENTS HOFFMANN-LA ROCHE INC. (US) 1987-03-10 US disclosed
EP-0066351-B1 ARYLETHANOL AMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS BEECHAM GROUP PLC (GB) 1985-06-26 EP disclosed
EP-0066351-A1 Arylethanol amine derivatives, their preparation and use in pharmaceutical compositions BEECHAM GROUP PLC (GB) 1982-12-08 EP disclosed
EP-0041233-A1 Substituted phenoxy-aminopropanol derivatives, intermediates and processes for their production, and pharmaceutical preparations containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-12-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030125356-A1 Cdk inhibitors having 3-hydroxychromen-4-one structure CDK4, CDK3, CDK6 SMN1; SMN2 4162/4885NPC1 4376/4885RAB9A 4302/4885
US-20230357134-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS TTR, C1R, APOB SMN1; SMN2 1033/4885NPC1 1272/4885RAB9A 3795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.