Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 7/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYBB | P04839 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269789 | 0.86 | NOX4 (0.51) | NOX4NOX1MGLLPGRGAA | |
| SCHEMBL11269792 | 0.86 | NOX4 (0.51) | NOX4NOX1MGLLPGRGAA | |
| SCHEMBL11277684 | 0.76 | ALDH1A1 (0.49) | NOX4NOX1CYBBGAAALDH1A1 | |
| SCHEMBL11277679 | 0.76 | ALDH1A1 (0.49) | NOX4NOX1CYBBGAAALDH1A1 | |
| SCHEMBL11275254 | 0.73 | HSP90AA1 (0.46) | NOX4NOX1MGLLGAAALDH1A1 | |
| SCHEMBL11275245 | 0.73 | HSP90AA1 (0.46) | NOX4NOX1MGLLGAAALDH1A1 | |
| SCHEMBL11277409 | 0.71 | MEN1 (0.51) | NOX4NOX1MGLLGAAALDH1A1 | |
| SCHEMBL11277401 | 0.71 | MEN1 (0.51) | NOX4NOX1MGLLGAAALDH1A1 | |
| SCHEMBL11607013 | 0.70 | MGLL (0.58) | MGLLPGRGAAALDH1A1MAPT | |
| SCHEMBL11282741 | 0.70 | BCL2A1 (0.52) | GAAALDH1A1MAPTBCL2A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859228-A | Novel 5-aminomethylene-2,4-imidazolidinediones and 5-aminomethylene-2-thionoimidazolidine-4-ones | ICI AMERICAS INC (US) | 1989-08-22 | — | — | US | disclosed |
| EP-0300882-A2 | Novel 5-Aminomethylene-2,4-imidazolidinediones and 5-aminomethylene-2-thionoimidazolidine-4-ones | ICI AMERICAS INC. (US) | 1989-01-25 | — | — | EP | disclosed |