Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28814222 | 0.79 | IDH1 (0.46) | PARP1MEN1KMT2A | |
| SCHEMBL4505211 | 0.78 | GAA (0.55) | MAPTKMT2AGAAGFERPPIA | |
| SCHEMBL10515778 | 0.77 | MAPT (0.47) | MAPTMEN1KMT2AGAAHDAC3 | |
| SCHEMBL5211495 | 0.76 | PDK1 (0.55) | PDK1MAPTGAAGFERPPIA | |
| SCHEMBL10647146 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2AGAAGFER | |
| SCHEMBL2557430 | 0.76 | CFD (0.55) | MAPTGAAGFERNOS3NOS1 | |
| SCHEMBL2569068 | 0.75 | NOS1 (0.51) | PARP1MAPTGAAGFERNOS3 | |
| SCHEMBL5031452 | 0.74 | SIGMAR1 (0.60) | MAPTMEN1KMT2AGAAHDAC3 | |
| SCHEMBL13564689 | 0.74 | MAPT (0.46) | PDK1MAPTMEN1KMT2AGAA | |
| SCHEMBL5212905 | 0.74 | MAPT (0.46) | PARP1MAPTGAAGFERPPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329169-A1 | N-(lower alkyl)-2-(3'-ureidobenzyl)-pyrrolidines | SYNTEX (U.S.A.) INC. (US) | 1989-08-23 | — | — | EP | disclosed |
| US-4826869-A | GLAUCOMA | SYNTEX (U.S.A.) INC. (US) | 1989-05-02 | — | — | US | disclosed |