Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516254 | 0.82 | TSHR (0.49) | RAB9AKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL11669735 | 0.82 | TSHR (0.56) | RAB9AKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL11377800 | 0.81 | CA12 (0.64) | TSHRALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL10514703 | 0.79 | MAPK1 (0.48) | KMT2AMEN1TSHRALDH1A1MAPT | |
| SCHEMBL11377261 | 0.79 | ALDH1A1 (0.49) | KMT2AMEN1TSHRALDH1A1MAPT | |
| SCHEMBL25386200 | 0.78 | ALDH1A1 (0.52) | RAB9AKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL11669017 | 0.78 | TSHR (0.51) | RAB9AKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL10516835 | 0.76 | TSHR (0.50) | RAB9ATSHRALDH1A1MAPTNPC1 | |
| SCHEMBL11792053 | 0.75 | RAB9A (0.49) | RAB9AKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL1898535 | 0.75 | TSHR (0.67) | KMT2AMEN1TSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299663-A2 | Antihistaminic aromatic tetrahydroazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1989-01-18 | — | — | EP | disclosed |
| US-4746657-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-05-24 | — | — | US | disclosed |