Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597713 | 0.91 | TSHR (0.56) | TSHRALDH1A1HSD17B10L3MBTL1PKM | |
| SCHEMBL7422565 | 0.89 | TSHR (0.51) | TSHRALDH1A1HSD17B10L3MBTL1PKM | |
| SCHEMBL2644268 | 0.88 | TSHR (0.56) | TSHRALDH1A1HSD17B10L3MBTL1PKM | |
| SCHEMBL1567252 | 0.86 | TSHR (0.52) | TSHRALDH1A1HSD17B10L3MBTL1PKM | |
| SCHEMBL13032652 | 0.86 | TSHR (0.67) | TSHRALDH1A1HSD17B10L3MBTL1CDC25B | |
| SCHEMBL28600642 | 0.86 | TSHR (0.52) | TSHRALDH1A1HSD17B10L3MBTL1PKM | |
| SCHEMBL6959476 | 0.86 | TSHR (0.67) | TSHRALDH1A1HSD17B10L3MBTL1CDC25B | |
| SCHEMBL1492385 | 0.86 | TSHR (0.67) | TSHRALDH1A1HSD17B10L3MBTL1CDC25B | |
| SCHEMBL10724543 | 0.86 | L3MBTL1 (0.53) | TSHRALDH1A1HSD17B10L3MBTL1PKM | |
| SCHEMBL578128 | 0.85 | TSHR (0.77) | TSHRALDH1A1HSD17B10L3MBTL1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796313-B2 | Substituted dihydroisoindolones as allosteric modulators of glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-08-05 | — | — | US | disclosed |
| US-20130072519-A1 | 2-PHENYL BENZOYLAMIDES | CONN EDWARD LEE (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072519-A1 | 2-PHENYL BENZOYLAMIDES | CONN EDWARD LEE (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072519-A1 | 2-PHENYL BENZOYLAMIDES | CONN EDWARD LEE (US) | 2013-03-21 | — | — | US | disclosed |
| US-7935832-B2 | Pyrrole and isoindole carboxamide derivatives as P2X7 modulators | GLAXO GROUP LIMITED (GB) | 2011-05-03 | — | — | US | disclosed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| US-20100210705-A1 | Pyrrole and Isoindole Carboxamide Derivatives as P2X7 Modulators | GLAXO GROUP LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| EP-2142502-A1 | PYRROLE AND ISOINDOLE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008116814-A1 | PYRROLE AND ISOINDOLE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
| EP-1960385-A1 | SUBSTITUTED DIHYDROISOINDOLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-27 | — | — | EP | disclosed |
| US-20070099930-A1 | Substituted Dihydroisoindolones As Allosteric Modulators of Glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | US | disclosed |
| EP-0834497-B1 | PROCESS FOR PRODUCING 3-ISOCHROMANONES | SAGAMI CHEM RES (JP) | 2001-10-24 | — | — | EP | disclosed |
| EP-0549352-B1 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO KK (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5886211-A | Process for producing 2-(halomethyl)phenylacetic acid esters | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0834497-A1 | PROCESS FOR PRODUCING 2-(HALOMETHYL)PHENYLACETIC ACID ESTERS | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1998-04-08 | — | — | EP | disclosed |
| US-5607955-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
| US-4273773-A | IN COMBINATION WITH A DIURETIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072519-A1 | 2-PHENYL BENZOYLAMIDES | APOB, MTTP, HADHB | TSHR 3186/4885ALDH1A1 885/4885HSD17B10 191/4885 |
| US-20070099930-A1 | Substituted Dihydroisoindolones As Allosteric Modulators of Glucokinase | GCK, GCKR, GPR119 | TSHR 3340/4885ALDH1A1 1552/4885HSD17B10 717/4885 |
| US-20100210705-A1 | Pyrrole and Isoindole Carboxamide Derivatives as P2X7 Modulators | P2RX3, P2RX6, P2RY6 | TSHR 1052/4885ALDH1A1 2500/4885HSD17B10 4389/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | TSHR 1483/4885ALDH1A1 310/4885HSD17B10 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.