Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519718 | 1.00 | HRH4 (0.52) | HRH4KMT2ACTNNB1KDM4EGSK3B | |
| SCHEMBL10520185 | 0.91 | HRH4 (0.54) | HRH4KMT2AMEN1MAPTCHRNB2 | |
| SCHEMBL7291021 | 0.90 | KMT2A (0.57) | HRH4KMT2ACTNNB1MEN1HPGD | |
| SCHEMBL10520925 | 0.90 | KMT2A (0.57) | HRH4KMT2ACTNNB1MEN1HPGD | |
| SCHEMBL10749706 | 0.88 | MME (0.49) | HRH4CTNNB1CPA1TDP1 | |
| SCHEMBL7288450 | 0.85 | EPHX1 (0.47) | HRH4KMT2ACTNNB1MEN1CPA1 | |
| SCHEMBL10520573 | 0.83 | MEN1 (0.53) | HRH4KMT2ACTNNB1KDM4EMEN1 | |
| SCHEMBL9013764 | 0.83 | CYP1A2 (0.47) | HRH4CTNNB1HPGDCPA1 | |
| SCHEMBL7352579 | 0.82 | CYP1A2 (0.65) | HRH4KMT2ACTNNB1MEN1SLC1A1 | |
| SCHEMBL10338654 | 0.82 | CPA1 (0.57) | HRH4CTNNB1SLC1A1HPGDCPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |