Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.50 |
| ▸ | MMP8 | P22894 | 10/20 | 0.50 |
| ▸ | MMP9 | P14780 | 9/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 10/20 | 0.45 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MMP15 | P51511 | 1/20 | 0.45 |
| ▸ | MMP16 | P51512 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.45 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.45 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522487 | 0.91 | MMP2 (0.51) | MMP2MMP8MMP9MMP1MMP7 | |
| SCHEMBL10521185 | 0.90 | CASP1 (0.47) | MMP2MMP8MMP9CASP1 | |
| SCHEMBL10520558 | 0.87 | MMP9 (0.47) | MMP2MMP8MMP9CASP1MMP1 | |
| SCHEMBL10521511 | 0.81 | MMP2 (0.46) | MMP2MMP8MMP9 | |
| SCHEMBL10520279 | 0.80 | CAPN1 (0.47) | MMP2MMP8MMP9MMP1 | |
| SCHEMBL10519671 | 0.79 | CAPN1 (0.46) | MMP2MMP8MMP9MMP1MMP3 | |
| SCHEMBL10522756 | 0.79 | REN (0.43) | MMP2MMP8MMP9MMP14 | |
| SCHEMBL10521251 | 0.79 | MMP9 (0.44) | MMP2MMP8MMP9MMP14 | |
| SCHEMBL10897328 | 0.79 | MMP9 (0.44) | MMP2MMP8MMP9MMP14 | |
| SCHEMBL10571933 | 0.79 | REN (0.49) | MMP2MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |