Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.53 |
| ▸ | AANAT | Q16613 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519877 | 0.87 | AANAT (0.57) | MTNR1AAANATMEN1KMT2AMAPT | |
| SCHEMBL9302879 | 0.77 | MEN1 (0.71) | MTNR1AAANATMEN1KMT2AMAPT | |
| SCHEMBL7617021 | 0.76 | HDAC8 (0.67) | AANATMEN1KMT2AMAPTLMNA | |
| SCHEMBL9554950 | 0.75 | MMP2 (0.53) | MTNR1ALMNACYP1A2CYP2C19KDM4E | |
| SCHEMBL10523023 | 0.74 | CTNNB1 (0.49) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| SCHEMBL761155 | 0.74 | MTNR1A (0.76) | MTNR1AAANATMEN1KMT2AMAPT | |
| SCHEMBL31114206 | 0.74 | MTNR1A (0.76) | MTNR1AAANATMEN1KMT2AMAPT | |
| SCHEMBL2824958 | 0.74 | AANAT (0.67) | MTNR1AAANATMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL3826492 | 0.73 | MTNR1A (0.74) | MTNR1AAANATMEN1KMT2AMAPT | |
| SCHEMBL761481 | 0.73 | MTNR1A (0.88) | MTNR1AAANATMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |