Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.50 |
| ▸ | CTSL | P07711 | 5/20 | 0.50 |
| ▸ | CTSS | P25774 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10636524 | 0.88 | CTSK (0.54) | CTSKCTSLCTSSPTPN1PSMB1 | |
| SCHEMBL10477854 | 0.85 | CTSK (0.50) | CTSKCTSLCTSSHDAC8MMP1 | |
| SCHEMBL10978997 | 0.85 | CTSK (0.50) | CTSKCTSLPTPN1PSMB1PSMB5 | |
| SCHEMBL7385168 | 0.84 | HDAC8 (0.47) | CTSKCTSLCTSSHDAC8F2 | |
| SCHEMBL7382971 | 0.84 | ATM (0.48) | CTSKCTSLCTSSHDAC8F2 | |
| SCHEMBL9830940 | 0.83 | ATM (0.53) | CTSKCTSLCTSSHDAC8PTPN1 | |
| SCHEMBL9830929 | 0.83 | ATM (0.53) | CTSKCTSLCTSSHDAC8PTPN1 | |
| SCHEMBL10982494 | 0.82 | CTSL (0.53) | CTSKCTSLCTSB | |
| SCHEMBL10976366 | 0.81 | REN (0.58) | CTSKCTSLMMP9PSMB1PSMB5 | |
| SCHEMBL10633366 | 0.81 | REN (0.58) | CTSKCTSLMMP9PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |