Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830940 | 0.92 | ATM (0.53) | ATMHDAC8ALDH1A1CTSLCTSS | |
| SCHEMBL9830929 | 0.92 | ATM (0.53) | ATMHDAC8ALDH1A1CTSLCTSS | |
| SCHEMBL7385168 | 0.89 | HDAC8 (0.47) | ATMHDAC8ALDH1A1CTSLCTSS | |
| SCHEMBL29401219 | 0.89 | ALDH1A1 (0.54) | ATMALDH1A1CTSLCTSSCTSK | |
| SCHEMBL7383353 | 0.87 | ATM (0.47) | ATMHDAC8CTSLCTSSCTSK | |
| SCHEMBL10521291 | 0.84 | CTSK (0.50) | ATMHDAC8CTSLCTSSCTSK | |
| SCHEMBL9666956 | 0.83 | CTSL (0.54) | ALDH1A1CTSLCTSSCTSKALOX15 | |
| SCHEMBL9551368 | 0.83 | CTSL (0.54) | ALDH1A1CTSLCTSSCTSKALOX15 | |
| SCHEMBL9551274 | 0.83 | CTSL (0.54) | ALDH1A1CTSLCTSSCTSKALOX15 | |
| SCHEMBL27343926 | 0.83 | CTSL (0.54) | ALDH1A1CTSLCTSSCTSKALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870183-A | RENIN INHIBITORS, HYPOTENSIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4857650-A | Novel renin inhibitory amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0252727-A1 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-01-13 | — | — | EP | disclosed |
| EP-0206807-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-12-30 | — | — | EP | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |