Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | NMBR | P28336 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10872017 | 0.93 | HRH4 (0.50) | HRH4PTPN1MMP2MMP9MMP8 | |
| SCHEMBL10522999 | 0.90 | KMT2A (0.44) | HRH4RENMMP2MMP9MMP8 | |
| SCHEMBL10570967 | 0.89 | HRH4 (0.47) | HRH4RENMMP2MMP9MMP8 | |
| SCHEMBL10570975 | 0.89 | HRH4 (0.47) | HRH4RENMMP2MMP9MMP8 | |
| SCHEMBL10825063 | 0.89 | REN (0.48) | REN | |
| SCHEMBL10522100 | 0.87 | HRH4 (0.43) | HRH4RENMMP2MMP9MMP8 | |
| SCHEMBL10521511 | 0.86 | MMP2 (0.46) | RENMMP2MMP9MMP8 | |
| SCHEMBL8486193 | 0.86 | HRH4 (0.45) | HRH4ANPEPERAP2ERAP1REN | |
| SCHEMBL8486197 | 0.86 | HRH4 (0.45) | HRH4ANPEPERAP2ERAP1REN | |
| SCHEMBL10520319 | 0.86 | HRH4 (0.44) | HRH4BIRC2ANPEPERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4841067-A | RENIN INHIBITORS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| EP-0190891-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-08-13 | — | — | EP | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |