Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | FCER2 | P06734 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521511 | 0.93 | MMP2 (0.46) | MMP8MMP2MMP9REN | |
| SCHEMBL10872017 | 0.91 | HRH4 (0.50) | HRH4MMP1FCER2MMP8MMP3 | |
| SCHEMBL10522999 | 0.89 | KMT2A (0.44) | HRH4MMP1FCER2MMP8MMP3 | |
| SCHEMBL10519796 | 0.87 | MMP9 (0.47) | MMP1FCER2MMP8MMP2MMP9 | |
| SCHEMBL10570967 | 0.87 | HRH4 (0.47) | HRH4MMP1FCER2MMP8MMP3 | |
| SCHEMBL10522366 | 0.87 | HRH4 (0.42) | HRH4MMP8MMP2MMP9REN | |
| SCHEMBL10570975 | 0.87 | HRH4 (0.47) | HRH4MMP1FCER2MMP8MMP3 | |
| SCHEMBL8487755 | 0.85 | HRH4 (0.48) | HRH4CYP3A4BRS3 | |
| SCHEMBL8487752 | 0.85 | HRH4 (0.48) | HRH4CYP3A4BRS3 | |
| SCHEMBL10521185 | 0.85 | CASP1 (0.47) | MMP8MMP2MMP9REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |