Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | MMP8 | P22894 | 3/20 | 0.37 |
| ▸ | MMP14 | P50281 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521853 | 0.85 | SMN1; SMN2 (0.36) | ANPEPPSMB5MMP2PSMB8MMP3 | |
| SCHEMBL10522966 | 0.84 | REN (0.35) | PSMB5MMP9MMP8MMP14MMP2 | |
| SCHEMBL10522964 | 0.84 | REN (0.35) | PSMB5MMP9MMP8MMP14MMP2 | |
| SCHEMBL10897999 | 0.83 | PSMB5 (0.45) | ANPEPPSMB5MMP9MMP8MMP2 | |
| SCHEMBL10523789 | 0.82 | HRH4 (0.36) | ANPEPPSMB5MMP9MMP8MMP14 | |
| SCHEMBL10520558 | 0.82 | MMP9 (0.47) | CASP1MMP9MMP8MMP2REN | |
| SCHEMBL10521381 | 0.80 | PSMB5 (0.42) | PSMB5CASP1MMP9MMP8MMP2 | |
| SCHEMBL10521251 | 0.80 | MMP9 (0.44) | ANPEPPSMB5MMP9MMP8MMP14 | |
| SCHEMBL10897328 | 0.80 | MMP9 (0.44) | ANPEPPSMB5MMP9MMP8MMP14 | |
| SCHEMBL10520125 | 0.78 | MMP9 (0.42) | ANPEPPSMB5MMP9MMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |