Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 7/20 | 0.34 |
| ▸ | CTSB | P07858 | 4/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.30 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522966 | 1.00 | REN (0.35) | RENCAPN1CTSBMMP9MMP8 | |
| SCHEMBL10519245 | 0.88 | MMP9 (0.32) | MMP9MMP8MMP14MMP2 | |
| SCHEMBL10519252 | 0.88 | MMP9 (0.32) | MMP9MMP8MMP14MMP2 | |
| SCHEMBL10521837 | 0.86 | ALDH1A1 (0.33) | MMP9MMP2 | |
| SCHEMBL10521842 | 0.86 | ALDH1A1 (0.33) | MMP9MMP2 | |
| SCHEMBL10522976 | 0.84 | ANPEP (0.40) | RENCAPN1MMP9MMP8MMP14 | |
| SCHEMBL10519172 | 0.84 | REN (0.40) | RENCAPN1MMP9MMP8 | |
| SCHEMBL10520337 | 0.82 | CTSB (0.39) | RENCAPN1CTSBMMP8PSMB5 | |
| SCHEMBL10897328 | 0.75 | MMP9 (0.44) | RENCAPN1CTSBMMP9MMP8 | |
| SCHEMBL10521251 | 0.75 | MMP9 (0.44) | RENCAPN1CTSBMMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |