Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10523190 | 1.00 | MEN1 (0.48) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL10520133 | 0.88 | KDM4E (0.48) | MEN1KMT2AKDM4EALDH1A1TRPV1 | |
| SCHEMBL10520127 | 0.88 | KDM4E (0.48) | MEN1KMT2AKDM4EALDH1A1TRPV1 | |
| SCHEMBL9555122 | 0.80 | ALDH1A1 (0.58) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL9555118 | 0.80 | ALDH1A1 (0.58) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL7328215 | 0.80 | KDM4E (0.51) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL7328223 | 0.80 | KDM4E (0.51) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL5698294 | 0.75 | KDM4E (0.52) | MEN1KMT2AKDM4EALDH1A1HDAC8 | |
| SCHEMBL10477791 | 0.75 | KDM4E (0.50) | MEN1KMT2AKDM4EALDH1A1HDAC8 | |
| SCHEMBL10477792 | 0.75 | KDM4E (0.50) | MEN1KMT2AKDM4EALDH1A1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4841067-A | RENIN INHIBITORS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| EP-0190891-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-08-13 | — | — | EP | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |