Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526846 | 0.91 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL10908923 | 0.87 | HPGD (0.46) | NPC1RAB9ALTA4HTDP1L3MBTL1 | |
| SCHEMBL10910843 | 0.85 | LTA4H (0.47) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL27940429 | 0.84 | THRB (0.59) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL10336969 | 0.84 | THRB (0.59) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL10724161 | 0.82 | HDAC1 (0.60) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL28578725 | 0.82 | HDAC1 (0.60) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL10906771 | 0.82 | MAPT (0.49) | SMN1; SMN2TSHRLTA4HTDP1L3MBTL1 | |
| SCHEMBL7576079 | 0.81 | THRB (0.62) | NPC1RAB9ASMN1; SMN2TSHRTHRB | |
| SCHEMBL2762361 | 0.80 | SMN1; SMN2 (0.63) | SMN1; SMN2LTA4HALOX5ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845235-A | Pyrroline derivative | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1989-07-04 | — | — | US | disclosed |