Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27476871 | 0.98 | MEN1 (0.58) | MEN1KMT2ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL20536090 | 0.87 | CYP2D6 (0.54) | MEN1KMT2ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL4392254 | 0.79 | CYP2D6 (0.45) | MEN1KMT2AKCNH2OPRD1SLC6A3 | |
| SCHEMBL27484196 | 0.78 | MEN1 (0.54) | MEN1KMT2ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL19974184 | 0.78 | MEN1 (0.54) | MEN1KMT2ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL28041845 | 0.77 | CYP2D6 (0.40) | MEN1KMT2AKCNH2OPRD1SLC6A3 | |
| SCHEMBL28816744 | 0.76 | MEN1 (0.51) | MEN1KMT2ASLC6A4SLC6A2OPRD1 | |
| SCHEMBL42790 | 0.76 | CYP2D6 (0.73) | MEN1KMT2ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL3956861 | 0.76 | CYP2D6 (0.73) | MEN1KMT2ASLC6A4SLC6A2KCNH2 | |
| SCHEMBL3950480 | 0.76 | CYP2D6 (0.73) | MEN1KMT2ASLC6A4SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103204862-B | 6-phenylimidazol[2, 1-b]thiazole-3-amide derivative, its preparation method and application | UNIV TSINGHUA GRADUATE SCHOOL | 2014-12-17 | — | — | CN | claimed |
| CN-103204862-A | 6-phenylimidazol[2, 1-b]thiazole-3-amide derivative, its preparation method and application | UNIV TSINGHUA GRADUATE SCHOOL | 2013-07-17 | — | — | CN | claimed |
| CN-103204824-A | 2-aminothiazole-4-amide derivative, its preparation method and application | UNIV TSINGHUA GRADUATE SCHOOL | 2013-07-17 | — | — | CN | claimed |
| EP-3094332-A1 | CARBONYL ERASTIN ANALOGS AND THEIR USE | The Trustees of Columbia University in the City of New York (US) | 2016-11-23 | — | — | EP | disclosed |
| US-9249115-B2 | N,N1 substituted piperazines having combined antiaggregant, anticoagulant and vasodilatory activity, and method for producing same | VERTEX CLOSED JOINT STOCK COMPANY (RU) | 2016-02-02 | — | — | US | disclosed |
| WO-2015109009-A1 | CARBONYL ERASTIN ANALOGS AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-07-23 | — | — | WO | disclosed |
| CN-103204824-B | 2-aminothiazole-4-amide derivative, its preparation method and application | UNIV TSINGHUA GRADUATE SCHOOL | 2015-04-08 | — | — | CN | disclosed |
| CN-103204862-B | 6-phenylimidazol[2, 1-b]thiazole-3-amide derivative, its preparation method and application | UNIV TSINGHUA GRADUATE SCHOOL | 2014-12-17 | — | — | CN | disclosed |
| CN-102796037-B | 3-(4-(4-substituted-piperazino)-1-butyryl)indolyl-5-formonitrile and application thereof | CHENGDU WANDONG PAHRMACEUTICAL CO LTD | 2013-11-06 | — | — | CN | disclosed |
| US-20130267707-A1 | N,N+hu 1 +l SUBSTITUTED PIPERAZINES HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATORY ACTIVITY, AND METHOD FOR PRODUCING SAME | ZAKRYTOE AKTSIONERNOE OBSCHSHESTVO "VERTEX" (RU) | 2013-10-10 | — | — | US | disclosed |
| CN-103204862-A | 6-phenylimidazol[2, 1-b]thiazole-3-amide derivative, its preparation method and application | UNIV TSINGHUA GRADUATE SCHOOL | 2013-07-17 | — | — | CN | disclosed |
| CN-101619056-A | Benzothiophene alkanol piperazine derivatives and use thereof as antidepressant medicaments | ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2010-01-06 | — | — | CN | disclosed |
| CN-101490017-A | Therapeutic piperazines as PDE4 inhibitors | HELICON THERAPEUTICS INC (US) | 2009-07-22 | — | — | CN | disclosed |
| CN-1172919-C | Alkyl alcohol piperazine derivative and its application in preparing medicine for treating depression | 上海医药工业研究院 | 2004-10-27 | — | — | CN | disclosed |
| CN-1384102-A | Alkyl alcohol piperazine derivative and its application in preparing medicine for treating depression | SHANGHAI INST OF MEDICINAL IND (CN) | 2002-12-11 | — | — | CN | disclosed |
| EP-0144991-B1 | POLYMETHOXYBENZYL PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1989-03-29 | — | — | EP | disclosed |
| EP-0144991-B1 | POLYMETHOXYBENZYL PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1989-03-29 | — | — | EP | disclosed |
| US-4574156-A | Polymethoxybenzyl piperazine derivatives effective for improving blood circulation system | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1986-03-04 | — | — | US | disclosed |
| EP-0144991-A2 | Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |
| EP-0144991-A2 | Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267707-A1 | N,N+hu 1 +l SUBSTITUTED PIPERAZINES HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATORY ACTIVITY, AND METHOD FOR PRODUCING SAME | HCN1, HCN3, HCN2 | MEN1 879/4885KMT2A 2019/4885SLC6A4 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.