Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | AGXT | P21549 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21260405 | 0.81 | MAPT (0.49) | MAPTSMN1; SMN2IKBKBPKMIDO1 | |
| SCHEMBL18885166 | 0.79 | LMNA (0.31) | MAPTSMN1; SMN2 | |
| SCHEMBL5720468 | 0.77 | SLC6A4 (0.45) | PKMMPOHTR2ASLC6A4KCNH2 | |
| SCHEMBL8352769 | 0.77 | PLK1 (0.33) | MAPTSMN1; SMN2SLC6A4HTTALDH1A1 | |
| SCHEMBL2562083 | 0.76 | P2RX7 (0.38) | MAPTSMN1; SMN2IDO1AGXTMEN1 | |
| SCHEMBL12843995 | 0.76 | AOC1 (0.47) | MAPTSMN1; SMN2IKBKBMPOIDO1 | |
| SCHEMBL1122006 | 0.75 | IDO1 (0.48) | SMN1; SMN2IDO1AGXTHTR2AKCNH2 | |
| SCHEMBL29953348 | 0.75 | IDO1 (0.48) | SMN1; SMN2IDO1AGXTHTR2AKCNH2 | |
| SCHEMBL23175609 | 0.75 | HTR6 (0.48) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL24783702 | 0.75 | MAPT (0.34) | MAPTALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343206-A1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | The Boots Company PLC (GB) | 1989-11-29 | — | — | EP | disclosed |