Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.37 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | FADS1 | O60427 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10534373 | 0.92 | BCHE (0.35) | KDM1AMAOAMAOBGRIN2BTP53 | |
| SCHEMBL9565775 | 0.83 | TRPM5 (0.41) | TRPM4TRPM5ALOX12TP53HPGD | |
| SCHEMBL11099067 | 0.83 | ESR1 (0.41) | KDM1AMAOAMAOBTP53MDM2 | |
| SCHEMBL10534797 | 0.80 | PRCP (0.41) | GSK3BSMN1; SMN2HTR2AHTR2CSIGMAR1 | |
| SCHEMBL44650 | 0.79 | SIGMAR1 (0.44) | KDM1AMAOAMAOBGRIN2BGSK3B | |
| SCHEMBL24899246 | 0.70 | KDM1A (0.49) | KDM1AMAOAMAOBTRPM4TRPM5 | |
| SCHEMBL22072985 | 0.70 | KDM1A (0.49) | KDM1AMAOAMAOBTRPM4TRPM5 | |
| SCHEMBL27909263 | 0.70 | KDM1A (0.49) | KDM1AMAOAMAOBTRPM4TRPM5 | |
| SCHEMBL10534782 | 0.70 | HPGD (0.49) | TP53HPGDL3MBTL1GSK3BSMN1; SMN2 | |
| SCHEMBL6414384 | 0.67 | TSHR (0.36) | KDM1AMAOAMAOBSMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801593-A | VIRICIDE FOR RHINITIS VIRUS CONTAINING 2-PHENYLTETRALIN DERIVATIVE | BURROUGHS WELLCOME CO. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0025598-B1 | THE USE OF 2-PHENYLTETRALIN DERIVATIVES, OR HETEROCYCLIC ANALOGUES, IN MEDICINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-08-01 | — | — | EP | disclosed |
| EP-0025598-A1 | The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-03-25 | — | — | EP | disclosed |