Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Catechol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.33 |
| ▸ | PKLR known ✓ | P30613 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechol SCHEMBL1143838 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Catechol SCHEMBL29652083 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Catechol SCHEMBL235068 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Catechol SCHEMBL27989011 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Catechol SCHEMBL23111816 | 0.82 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Catechol SCHEMBL11405646 | 0.82 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Catechol SCHEMBL11778548 | 0.74 | SMN1; SMN2 (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2CA2 | |
| Sulfuric Acid SCHEMBL16448274 | 0.72 | CA5A (0.55) | KDM4EALDH1A1CA2CA4CA5A | |
| Sulfuric Acid SCHEMBL3650810 | 0.72 | CA5A (0.55) | KDM4EALDH1A1CA2CA4CA5A | |
| Sulfuric Acid SCHEMBL28642679 | 0.72 | CA5A (0.55) | KDM4EALDH1A1CA2CA4CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861715-A | FERMENTATIVE CULTURE PRODUCT OF STREPTOMYCES; STREPTOTHRICIN-TYPE GLYCOSIDE ANTIBIOTIC | VEB JENAPHARM (DD) | 1989-08-29 | — | — | US | disclosed |