Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8817667 | 0.88 | SMN1; SMN2 (0.56) | GSK3BSMN1; SMN2LMNAKDM4ECRHBP | |
| SCHEMBL10537698 | 0.86 | VHL (0.47) | GSK3BSMN1; SMN2LMNANPSR1KDM4E | |
| SCHEMBL10534782 | 0.83 | HPGD (0.49) | GSK3BSMN1; SMN2LMNANPSR1KDM4E | |
| SCHEMBL21982716 | 0.72 | SIGMAR1 (0.41) | GSK3BSMN1; SMN2KDM4ECRHBPCRHR2 | |
| SCHEMBL11374339 | 0.71 | POLB (0.47) | GSK3BSMN1; SMN2LMNANPSR1KDM4E | |
| SCHEMBL68859 | 0.70 | ALDH1A1 (0.57) | GSK3BSMN1; SMN2KDM4EHTTPOLB | |
| SCHEMBL10814919 | 0.70 | SIGMAR1 (0.47) | GSK3BSMN1; SMN2KDM4EUSP2POLB | |
| SCHEMBL8373688 | 0.70 | SIGMAR1 (0.43) | GSK3BSMN1; SMN2LMNAKDM4EHTT | |
| SCHEMBL28814207 | 0.70 | SIGMAR1 (0.43) | GSK3BSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL6001645 | 0.70 | RAB9A (0.49) | SMN1; SMN2LMNANPSR1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801593-A | VIRICIDE FOR RHINITIS VIRUS CONTAINING 2-PHENYLTETRALIN DERIVATIVE | BURROUGHS WELLCOME CO. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0025598-B1 | THE USE OF 2-PHENYLTETRALIN DERIVATIVES, OR HETEROCYCLIC ANALOGUES, IN MEDICINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-08-01 | — | — | EP | disclosed |
| EP-0025598-A1 | The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-03-25 | — | — | EP | disclosed |