Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063731 | 0.84 | PNP (0.43) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL10537739 | 0.84 | PNP (0.46) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL11069322 | 0.84 | GAA (0.44) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL10541524 | 0.82 | PDE4A (0.43) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL10542779 | 0.80 | PNP (0.40) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL11068022 | 0.75 | MAT2A (0.42) | SMN1; SMN2CYP11B2HPGDHTTGRM1 | |
| SCHEMBL11067389 | 0.74 | PNP (0.46) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL10541825 | 0.74 | ADORA2B (0.45) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL10538565 | 0.71 | YTHDC1 (0.44) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 | |
| SCHEMBL10537750 | 0.70 | CYP11B1 (0.43) | PNPADORA2BSMN1; SMN2RXFP1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE33125-E | HYPOTENSIVE AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1989-12-05 | — | — | US | disclosed |
| US-4460585-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1984-07-17 | — | — | US | disclosed |