Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10539269 | 0.86 | RAB9A (0.35) | KMT2APDE7AMAPK10 | |
| SCHEMBL10652126 | 0.77 | KMT2A (0.33) | KMT2AACE | |
| SCHEMBL2460519 | 0.74 | KMT2A (0.45) | KMT2AKDM4CACEL3MBTL1NOS3 | |
| SCHEMBL10543054 | 0.72 | NOS3 (0.33) | NOS3NOS2 | |
| SCHEMBL9459194 | 0.71 | NPC1 (0.36) | KMT2AACEL3MBTL1POLB | |
| SCHEMBL6404425 | 0.70 | RYR2 (0.41) | KMT2AMCL1 | |
| SCHEMBL8637911 | 0.70 | AKR1C3 (0.46) | KMT2AACE | |
| SCHEMBL13851468 | 0.69 | KMT2A (0.68) | KMT2AKDM4CACEL3MBTL1NOS3 | |
| SCHEMBL21962476 | 0.67 | DRD2 (0.43) | KMT2AKDM4CACEPOLB | |
| SCHEMBL9209684 | 0.66 | NOTUM (0.38) | KMT2ANOS3NOS2POLBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816474-A | CENTRAL NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1989-03-28 | — | — | US | disclosed |
| EP-0280268-A1 | Thienothiopyrans | CIBA-GEIGY AG (CH) | 1988-08-31 | — | — | EP | disclosed |