Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10553867 | 0.79 | KMT2A (0.41) | MEN1KMT2ARCE1 | |
| Hydrochloric Acid SCHEMBL10550848 | 0.77 | HTT (0.33) | MEN1KMT2ARCE1 | |
| Hydrochloric Acid SCHEMBL10548475 | 0.71 | NOS3 (0.36) | MEN1KMT2ARCE1IDO1 | |
| Bromide SCHEMBL10744683 | 0.71 | CHAT (0.34) | — | |
| Hydrochloric Acid SCHEMBL10549556 | 0.69 | CHKA (0.33) | — | |
| Hydrochloric Acid SCHEMBL9487880 | 0.66 | MTNR1A (0.37) | — | |
| Hydrochloric Acid SCHEMBL10377992 | 0.66 | CHKA (0.37) | MEN1KMT2A | |
| SCHEMBL9593244 | 0.63 | CHKA (0.38) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9594289 | 0.62 | ALDH1A1 (0.32) | MEN1KMT2A | |
| SCHEMBL885161 | 0.62 | TP53 (0.42) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855420-A | Cephalosporin derivatives | ICI PHARMA (FR) | 1989-08-08 | — | — | US | disclosed |
| US-4678781-A | BACTERICIDAL ANTIBIOTICS | ICI PHARMA (FR) | 1987-07-07 | — | — | US | disclosed |