Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 5/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10548265 | 0.85 | THRA (0.41) | THRATHRBEPHX2PDE6DHPGD | |
| SCHEMBL10544853 | 0.83 | ALDH1A1 (0.45) | THRATHRBHPGDKMT2AMEN1 | |
| SCHEMBL10547959 | 0.73 | PSEN1 (0.50) | KMT2AMEN1TDP1ALDH1A1KDM4E | |
| SCHEMBL10546639 | 0.72 | KMT2A (0.43) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10546095 | 0.71 | KMT2A (0.44) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19458018 | 0.67 | HSD17B3 (0.55) | THRATHRBKMT2AMEN1TDP1 | |
| SCHEMBL10544258 | 0.67 | ALDH1A1 (0.47) | THRATHRBHPGDKMT2AMEN1 | |
| SCHEMBL1759008 | 0.65 | EPHX2 (0.54) | EPHX2KMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL12512504 | 0.65 | EPHX2 (0.50) | EPHX2KMT2AMEN1 | |
| SCHEMBL19458032 | 0.65 | HSD17B3 (0.53) | KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814341-A | HISTAMINE H2 ANTAGONISTS | REITER LAWRENCE A (US) | 1989-03-21 | — | — | US | disclosed |