Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549257 | 0.85 | THRA (0.41) | THRATHRBEPHX2PDE6DMEN1 | |
| SCHEMBL10544258 | 0.81 | ALDH1A1 (0.47) | THRATHRBMEN1KMT2ATDP1 | |
| SCHEMBL12512504 | 0.71 | EPHX2 (0.50) | EPHX2MEN1KMT2A | |
| SCHEMBL10548133 | 0.71 | PSEN1 (0.53) | MEN1KMT2ATDP1 | |
| SCHEMBL16297556 | 0.69 | EPHX2 (0.47) | EPHX2MEN1KMT2A | |
| SCHEMBL10547612 | 0.69 | KMT2A (0.43) | MEN1KMT2AMAOB | |
| SCHEMBL10422627 | 0.68 | EPHX2 (0.52) | THRATHRBEPHX2MEN1KMT2A | |
| SCHEMBL8365120 | 0.68 | EPHX2 (0.52) | THRATHRBEPHX2MEN1KMT2A | |
| SCHEMBL10423263 | 0.68 | EPHX2 (0.52) | THRATHRBEPHX2MEN1KMT2A | |
| SCHEMBL1759008 | 0.68 | EPHX2 (0.54) | EPHX2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814341-A | HISTAMINE H2 ANTAGONISTS | REITER LAWRENCE A (US) | 1989-03-21 | — | — | US | disclosed |