Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705442 | 0.88 | KDM4E (0.41) | AMY1AKDM4ECYP1A2CYP3A4PDE3B | |
| SCHEMBL10552590 | 0.85 | TP53 (0.38) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9703649 | 0.83 | AMY1A (0.43) | AMY1ATP53PDE3BPDE3APDE5A | |
| SCHEMBL10552928 | 0.83 | CDK4 (0.45) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10552771 | 0.82 | KDM4E (0.40) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10551871 | 0.82 | AMY1A (0.40) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9678840 | 0.79 | KDM4E (0.43) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10552087 | 0.79 | AMY1A (0.38) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10554215 | 0.78 | AMY1A (0.38) | AMY1ALMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9702924 | 0.78 | AMY1A (0.41) | AMY1ALMNAKDM4ECYP1A2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |