Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 11/20 | 0.41 |
| ▸ | PDE5A | O76074 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703649 | 0.86 | AMY1A (0.43) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL10852513 | 0.83 | AMY1A (0.40) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL9702805 | 0.82 | CDK4 (0.45) | AMY1APDE5APDE3BPDE3A | |
| SCHEMBL9705442 | 0.80 | KDM4E (0.41) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL10742305 | 0.80 | PDE5A (0.47) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL9704436 | 0.80 | PDE5A (0.43) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL10551908 | 0.78 | AMY1A (0.39) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL10373752 | 0.78 | PDE3B (0.48) | AMY1APDE5APDE3BPDE3APDE2A | |
| Isomazole SCHEMBL30578156 | 0.78 | PDE5A (0.51) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL10688962 | 0.78 | PDE2A (0.37) | AMY1APDE5APDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |