Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688158 | 0.85 | PDE3A (0.47) | PDE3BPDE3AGPR119PDE2APDE1A | |
| SCHEMBL10687147 | 0.83 | PDE3B (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10552154 | 0.76 | PDE3A (0.48) | PDE3BPDE3AGPR119PDE2APDE1A | |
| SCHEMBL10629606 | 0.73 | PDE3B (0.62) | PDE3BPDE3AGPR119PDE2APDE1A | |
| SCHEMBL10549976 | 0.67 | PDE3B (0.68) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10553122 | 0.64 | PDE3B (0.69) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL16157002 | 0.61 | PDE3B (0.61) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7296342 | 0.61 | PDE3B (0.61) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9781546 | 0.61 | BRD4 (0.54) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL7268042 | 0.60 | PDE3B (0.49) | PDE3BPDE3AGPR119PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |