Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9133220 | 0.82 | TDP1 (0.63) | LMNAKDM4EALDH1A1NPSR1TP53 | |
| SCHEMBL10552133 | 0.80 | KDM4E (0.44) | LMNAKDM4EALDH1A1NPSR1TP53 | |
| SCHEMBL10550459 | 0.78 | ALDH1A1 (0.60) | LMNAKDM4EALDH1A1NPSR1TP53 | |
| SCHEMBL27953738 | 0.78 | KMT2A (0.63) | LMNAKDM4EALDH1A1NPSR1HTT | |
| SCHEMBL10552718 | 0.76 | KDM4E (0.49) | LMNAKDM4EALDH1A1NPSR1TP53 | |
| SCHEMBL10549512 | 0.75 | KDM4E (0.49) | LMNAKDM4EALDH1A1NPSR1TP53 | |
| SCHEMBL10549122 | 0.75 | SMN1; SMN2 (0.49) | LMNAKDM4EALDH1A1TP53TDP1 | |
| SCHEMBL4156818 | 0.74 | PDK1 (0.51) | LMNAKDM4ETP53HTTTSHR | |
| SCHEMBL10549439 | 0.73 | ALDH1A1 (0.47) | LMNAKDM4EALDH1A1NPSR1TP53 | |
| SCHEMBL6716884 | 0.73 | PDK1 (0.51) | TP53HTTKMT2AHSD17B10PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847202-A | Heterocyclic inhibitors of serine proteases | GEORGIA TECH RESEARCH INSTITUTE (US) | 1989-07-11 | — | — | US | disclosed |
| US-4585793-A | Thioester inhibitors of serine proteases | GEORGIA TECH RESEARCH INSTITUTE (US) | 1986-04-29 | — | — | US | disclosed |