Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 11/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 11/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 11/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | CFB | P00751 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10558644 | 0.83 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL3751385 | 0.82 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL10556098 | 0.75 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL4564280 | 0.72 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL12883104 | 0.70 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1ACYP2D6 | |
| SCHEMBL30724675 | 0.70 | HDAC8 (0.47) | P2RX7MCHR1IDH1HTR1A | |
| SCHEMBL22092898 | 0.68 | IDH1 (0.39) | P2RX7MCHR1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL28647967 | 0.68 | IDH1 (0.39) | P2RX7MCHR1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL8275445 | 0.68 | PNMT (0.41) | MCHR1CYP2D6KCNH2CYP3A4SLC6A4 | |
| SCHEMBL24112177 | 0.67 | MAPK1 (0.39) | MCHR1IDH1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861789-A | Dihydro-indene-amine-dihydrooxazoles | BEECHAM GROUP PLC (GB) | 1989-08-29 | — | — | US | claimed |
| EP-0251453-A2 | Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-01-07 | — | — | EP | claimed |
| US-4861789-A | Dihydro-indene-amine-dihydrooxazoles | BEECHAM GROUP PLC (GB) | 1989-08-29 | — | — | US | disclosed |
| EP-0251453-A2 | Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-01-07 | — | — | EP | disclosed |