Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 15/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 13/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 13/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.46 |
| ▸ | CFB | P00751 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10552995 | 0.83 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL3751385 | 0.82 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL3738928 | 0.74 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL4564280 | 0.72 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL12883104 | 0.70 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL10556098 | 0.69 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL22547547 | 0.69 | ACHE (0.39) | CYP3A4CYP2D6GRIA2 | |
| SCHEMBL11974565 | 0.69 | ACHE (0.39) | CYP3A4CYP2D6GRIA2 | |
| SCHEMBL28640020 | 0.68 | GRIA2 (0.36) | GRIA2 | |
| Hydrochloric Acid SCHEMBL1026200 | 0.68 | ACHE (0.38) | CYP3A4CYP2D6GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861789-A | Dihydro-indene-amine-dihydrooxazoles | BEECHAM GROUP PLC (GB) | 1989-08-29 | — | — | US | claimed |
| EP-0251453-A2 | Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-01-07 | — | — | EP | claimed |
| US-4861789-A | Dihydro-indene-amine-dihydrooxazoles | BEECHAM GROUP PLC (GB) | 1989-08-29 | — | — | US | disclosed |
| EP-0251453-A2 | Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-01-07 | — | — | EP | disclosed |