Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 4/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555809 | 0.82 | KMT2A (0.69) | PDE1APDE1BPDE1CKMT2ALMNA | |
| SCHEMBL10554501 | 0.80 | KMT2A (0.46) | PDE1APDE1BPDE1CKMT2ALMNA | |
| SCHEMBL10553318 | 0.78 | KMT2A (0.56) | KMT2ALMNAMAPTMEN1CYP2C19 | |
| SCHEMBL10719101 | 0.78 | PRKAG1 (0.56) | KMT2ALMNAPDE2APDE3BPDE3A | |
| SCHEMBL9677526 | 0.77 | LMNA (0.54) | PDE1APDE1BPDE1CKMT2ALMNA | |
| SCHEMBL10551972 | 0.76 | MAPT (0.56) | KMT2ALMNAPDE2APDE3BPDE3A | |
| SCHEMBL10557944 | 0.76 | LMNA (0.53) | KMT2ALMNAPDE2APDE3BPDE3A | |
| SCHEMBL10553105 | 0.76 | LMNA (0.53) | PDE1APDE1BPDE1CKMT2ALMNA | |
| SCHEMBL9677242 | 0.76 | LMNA (0.53) | PDE1APDE1BPDE1CKMT2ALMNA | |
| SCHEMBL10551527 | 0.73 | LMNA (0.50) | PDE1APDE1BPDE1CKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0207483-A2 | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |