Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555809 | 0.90 | KMT2A (0.69) | KMT2ALMNAMAPTKDM4EMEN1 | |
| SCHEMBL10719101 | 0.80 | PRKAG1 (0.56) | KMT2ALMNAMAPTKDM4E | |
| SCHEMBL10553230 | 0.78 | PDE1A (0.56) | KMT2ALMNAMAPTMEN1CYP2C19 | |
| SCHEMBL10551972 | 0.78 | MAPT (0.56) | KMT2ALMNAMAPTKDM4E | |
| SCHEMBL10554501 | 0.77 | KMT2A (0.46) | KMT2ALMNAMAPTMEN1TDP1 | |
| SCHEMBL9721048 | 0.74 | KMT2A (0.58) | KMT2AGPR84MAPTPKMKDM4E | |
| SCHEMBL19025143 | 0.74 | KMT2A (0.58) | KMT2AGPR84MAPTPKMKDM4E | |
| SCHEMBL9720919 | 0.74 | KMT2A (0.58) | KMT2AGPR84MAPTPKMKDM4E | |
| SCHEMBL9677526 | 0.74 | LMNA (0.54) | KMT2ALMNAMAPTKDM4EMEN1 | |
| SCHEMBL10552435 | 0.73 | GPR84 (0.46) | KMT2AGPR84MAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |
| EP-0207483-A2 | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |