Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10719101 | 0.85 | PRKAG1 (0.56) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL10555809 | 0.82 | KMT2A (0.69) | MAPTKMT2AKDM4ELMNAPDE3B | |
| SCHEMBL10553318 | 0.78 | KMT2A (0.56) | MAPTKMT2AKDM4ELMNA | |
| SCHEMBL10553724 | 0.76 | MAPT (0.57) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL10553230 | 0.76 | PDE1A (0.56) | MAPTKMT2AALDH1A1LMNAPDE3B | |
| SCHEMBL14925453 | 0.75 | MAPT (0.72) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL10554501 | 0.72 | KMT2A (0.46) | MAPTKMT2AALDH1A1LMNAPDE3B | |
| SCHEMBL10662900 | 0.72 | MAPT (0.55) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL9677526 | 0.72 | LMNA (0.54) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL14930156 | 0.72 | MAPT (0.67) | MAPTKMT2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0207483-A2 | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |