Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869341 | 0.75 | POLB (0.38) | ALDH1A1MEN1KMT2ATDP1POLB | |
| SCHEMBL9869560 | 0.74 | RIPK2 (0.38) | TSHRGAARECQLKDM4E | |
| SCHEMBL18395054 | 0.68 | LMNA (0.48) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2424941 | 0.65 | KMT2A (0.55) | MAPTTSHRALDH1A1MEN1KMT2A | |
| Carbamic Acid SCHEMBL4197078 | 0.65 | CCNT1 (0.30) | — | |
| SCHEMBL13116713 | 0.65 | MAPK1 (0.49) | MAPTTSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL10556160 | 0.65 | KDM4E (0.70) | MAPTALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL181841 | 0.63 | ALDH1A1 (0.74) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL3111541 | 0.63 | CCNT1 (0.37) | — | |
| SCHEMBL11263201 | 0.63 | ALDH1A1 (0.47) | MAPTTSHRGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |