Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181841 | 0.79 | ALDH1A1 (0.74) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL28280303 | 0.75 | MAPT (0.49) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL15354269 | 0.71 | ALDH1A1 (1.00) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL19458027 | 0.71 | POLB (0.63) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL11928188 | 0.71 | KMT2A (0.57) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL29061555 | 0.70 | — | — | |
| SCHEMBL3953437 | 0.69 | ALDH1A1 (0.73) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL15233 | 0.69 | CES2 (1.00) | KMT2AALDH1A1MEN1POLBTHRB | |
| SCHEMBL2155972 | 0.69 | CES2 (1.00) | KMT2AALDH1A1MEN1POLBTHRB | |
| Piperazine SCHEMBL635835 | 0.69 | CES2 (0.52) | KMT2AALDH1A1MEN1POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |