Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FOS | P01100 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877335 | 0.79 | TRPM8 (0.60) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL9302644 | 0.77 | TRPM8 (0.58) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL9302651 | 0.77 | TRPM8 (0.58) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL25199560 | 0.77 | FOS (0.65) | TRPM8MAPTRAB9AKMT2AFOS | |
| Acrylic Acid SCHEMBL6862453 | 0.75 | KDM4E (0.59) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL10777127 | 0.75 | TRPM8 (0.55) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL26186292 | 0.74 | SMN1; SMN2 (0.57) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL28501196 | 0.72 | NPC1 (0.72) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL10271039 | 0.72 | TRPM8 (0.74) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL11217696 | 0.72 | HSD17B3 (0.55) | TRPM8MAPTRAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883877-A | CALCIUM METABOLISM REGULATORS, INHIBIT BONE RESORPTION, ANTIARTHRITIC | CIBA-GEIGY CORPORATION (US) | 1989-11-28 | — | — | US | disclosed |
| EP-0317506-A2 | Azabicycloheptanes and method for their preparation | CIBA-GEIGY AG (CH) | 1989-05-24 | — | — | EP | disclosed |