Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | FOS | P01100 | 1/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302651 | 0.83 | TRPM8 (0.58) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL10569133 | 0.83 | HSD11B1 (0.60) | MAPTKMT2AMAOAMAOBALOX5 | |
| SCHEMBL9302644 | 0.83 | TRPM8 (0.58) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL10457551 | 0.82 | ALOX5 (0.67) | TRPM8MAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL8993860 | 0.82 | ALOX5 (0.67) | TRPM8MAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL10777127 | 0.80 | TRPM8 (0.55) | TRPM8MAPTRAB9AKMT2AFOS | |
| SCHEMBL9877155 | 0.80 | HDAC2 (0.57) | TRPM8ALOX5PTGS1PTGS2 | |
| SCHEMBL6009904 | 0.80 | ALOX5 (0.63) | TRPM8MAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL6009895 | 0.80 | ALOX5 (0.63) | TRPM8MAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL10554666 | 0.79 | TRPM8 (0.54) | TRPM8MAPTRAB9AKMT2AFOS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4820828-A | BRONCHODILATOR AGENTS, ENZYME INHIBITORS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |