Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 20/20 | 0.57 |
| ▸ | INCENP | Q9NQS7 | 8/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1055248 | 0.96 | AURKA (0.53) | AURKAAURKBINCENP | |
| SCHEMBL12931309 | 0.93 | AURKA (0.49) | AURKAAURKBINCENP | |
| SCHEMBL12931291 | 0.91 | AURKA (0.50) | AURKAAURKBINCENP | |
| SCHEMBL1056889 | 0.90 | AURKA (0.52) | AURKAAURKBINCENP | |
| SCHEMBL1052439 | 0.90 | AURKA (0.54) | AURKAAURKBINCENP | |
| SCHEMBL1057136 | 0.89 | AURKA (0.71) | AURKAAURKBINCENP | |
| Trifluoroacetic Acid SCHEMBL1053464 | 0.89 | AURKA (0.49) | AURKAAURKBINCENP | |
| SCHEMBL1051982 | 0.85 | AURKA (0.56) | AURKAAURKBINCENP | |
| SCHEMBL1056423 | 0.84 | AURKA (0.53) | AURKAAURKBINCENP | |
| Hydrochloric Acid SCHEMBL1056573 | 0.84 | AURKA (0.52) | AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254888-B1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | MSD KK (JP) | 2014-12-24 | — | — | EP | claimed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | claimed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | claimed |
| EP-2254888-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-12-01 | — | — | EP | claimed |
| WO-2009104802-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-27 | — | — | WO | claimed |
| US-20180369224-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2018-12-27 | — | — | US | disclosed |
| US-10092556-B2 | Piperidine compound or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2018-10-09 | — | — | US | disclosed |
| US-20160228427-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
| US-20160228427-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
| US-20160228427-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
| EP-2821406-B1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-06-01 | — | — | EP | disclosed |
| EP-2821406-B1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-06-01 | — | — | EP | disclosed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | disclosed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2254888-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009104802-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009104802-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10092556-B2 | Piperidine compound or salt thereof | TUBB6, KIF5A, TUBB3 | AURKA 7/4885AURKB 30/4885INCENP 504/4885 |
| US-20180369224-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | CBR3, PRMT6, PRMT5 | AURKA 3455/4885AURKB 3610/4885INCENP 4038/4885 |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | AURKA, AURKC, AURKB | AURKA 1/4885AURKB 3/4885INCENP 88/4885 |
| US-20160228427-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | KIF5A, TUBB6, AURKC | AURKA 5/4885AURKB 21/4885INCENP 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.