Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.41 |
| ▸ | CYBB | P04839 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10559533 | 0.85 | P2RX3 (0.42) | ADORA3P2RX3HTT | |
| SCHEMBL9197469 | 0.85 | HPGD (0.51) | ADORA3P2RX3MEN1KMT2A | |
| SCHEMBL10559101 | 0.80 | P2RX3 (0.47) | ADORA3P2RX3KDM4EHTT | |
| SCHEMBL10560334 | 0.78 | P2RX3 (0.43) | P2RX3 | |
| SCHEMBL10564399 | 0.78 | RGS4 (0.44) | P2RX3MEN1HTTKMT2A | |
| SCHEMBL10561004 | 0.78 | HPGD (0.49) | ADORA3P2RX3MEN1KMT2A | |
| SCHEMBL10501681 | 0.78 | ALDH1A1 (0.41) | ADORA3P2RX3 | |
| SCHEMBL10562415 | 0.77 | TAAR1 (0.45) | ADORA3NOX4KDM4EMEN1HTT | |
| SCHEMBL10560450 | 0.75 | GSK3B (0.45) | — | |
| SCHEMBL10560343 | 0.74 | ADORA2A (0.43) | ADORA3KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0237289-A2 | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-16 | — | — | EP | disclosed |